The effects of responsibility frames and stigmatizing headlines in news on support for covid-19 policies in korea

This study examined the mechanisms through which responsibility frames and stigmatizing headlines influence support for governmental policies to address the pandemic. Based on a factorial design experiment, we examined the effects of 2 responsibility frames (individual vs. societal responsibility) and 4 headline types (non-stigmatized vs. name-stigmatized vs. characteristic-stigmatized vs. both-stigmatized). The results showed that the individual responsibility frame increased individual attribution of responsibility for the cause and spread of COVID-19 whereas reducing societal attribution of responsibility, compared to the societal responsibility frame. The headline that detailed both the stigmatized characteristic and name increased individual attribution of responsibility compared to the non-stigmatized headline. Furthermore, the effects of frames and headline types on policy support were sequentially mediated by attribution of responsibility and emotions. Individual attribution of responsibility led to anger whereas societal attribution of responsibility led to sympathy. Subsequently, anger increased support for punitive policies while sympathy increased support for assistive policies. This study contributes to the literature on news framing of pandemics by integrating cognitive and emotional mechanisms in forming policy attitudes. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

The Effects of Responsibility Frames and Stigmatizing Headlines in News on Support for COVID-19 Policies in Korea: The Mediating Roles of Responsibility Attribution and Emotions

This study examined the mechanisms through which responsibility frames and stigmatizing headlines influence support for governmental policies to address the pandemic. Based on a factorial design experiment, we examined the effects of 2 responsibility frames (individual vs. societal responsibility) and 4 headline types (non-stigmatized vs. name-stigmatized vs. characteristic-stigmatized vs. both-stigmatized). The results showed that the individual responsibility frame increased individual attribution of responsibility for the cause and spread of COVID-19 whereas reducing societal attribution of responsibility, compared to the societal responsibility frame. The headline that detailed both the stigmatized characteristic and name increased individual attribution of responsibility compared to the non-stigmatized headline. Furthermore, the effects of frames and headline types on policy support were sequentially mediated by attribution of responsibility and emotions. Individual attribution of responsibility led to anger whereas societal attribution of responsibility led to sympathy. Subsequently, anger increased support for punitive polices while sympathy increased support for assistive policies. This study contributes to the literature on news framing of pandemics by integrating cognitive and emotional mechanisms in forming policy attitudes. [ FROM AUTHOR] Copyright of Mass Communication & Society is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

The impact of COVID-19 misinformation and trust in institutions on preventive behaviors.

Misinformation related to coronavirus disease 2019 (COVID-19) has the potential to suppress preventive behaviors that mitigate the spread of COVID-19. Early research on the behavioral consequences of COVID-19 misinformation is mixed, and most rely on cross-sectional data. We examined whether believing in COVID-19 misinformation at one time point influences engaging in preventive behaviors later. In addition, we investigated the role of trust in institutions. We conducted a two-wave survey in South Korea and examined the association between belief in COVID-19 misinformation at Wave 1 and preventive behaviors at Wave 2 controlling for preventive behaviors at Wave 1. We also analyzed whether there is an interaction between belief in COVID-19 misinformation and trust in institutions. Belief in COVID-19 misinformation at Wave 1 significantly increased avoidance of preventive behaviors at Wave 2, but after accounting for trust in institutions, this effect disappeared. Rather, trust in institutions significantly decreased avoidance of preventive behaviors. In addition, misinformation increased avoidance of preventive behaviors among those who trusted institutions the most. Results suggest that building trust in institutions is essential in promoting COVID-19 preventive behaviors. Belief in COVID-19 misinformation may have harmful effects, but these effects were pronounced for those who highly trust institutions.

COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway. As a result, type I interferonopathies are exacerbated. Aspirin inhibits cGAS-mediated signaling through cGAS acetylation. Acetylation contributes to cGAS activity control and activates IFN-1 production and nuclear factor-κB (NF-κB) signaling via STING. Aspirin and dapsone inhibit the activation of both IFN-1 and NF-κB by targeting cGAS. We define these as anticatalytic mechanisms. It is necessary to alleviate the pathologic course and take the lag time of the odds of achieving viral clearance by day 7 to coordinate innate or adaptive immune cell reactions.

Communication Networks and Individual Resilience for Individual Well-Being During a Time of Crisis.

The deprivation of offline communication necessitated by the COVID-19 pandemic raises questions about whether and how external social resources and internal ability lead individuals to maintain their well-being. However, most research on the two factors, especially during the COVID-19 pandemic, has been based on cross-sectional survey data during the early lockdowns and focused on each factor separately. Combining the two lines of research, this study investigates how individuals' communication networks and resilience interacted with each other and influenced individual well-being at two time points during the COVID-19 pandemic. Based on the two-wave online panel survey data gathered from 708 Korean adults, this study suggests that individual well-being depends on strong ties and emotional support, and that their offline support influences their well-being differently depending on their level of resilience. Implications for understanding the transformed roles of communication networks and the complex dynamics of offline support together with individual resilience on individual well-being are discussed.

A comprehensive examination of association between belief in vaccine misinformation and vaccination intention in the COVID-19 context.

Misinformation about COVID-19 vaccines is widely available in the public communication environment. Exposure to the misinformation may increase perceived risk of and evoke negative emotions toward COVID-19 vaccines that may eventually reduce COVID-19 vaccination intentions. The negative influences of misinformation may vary by aspects of individuals' social networks. Expanding the reasoned action approach, we proposed a comprehensive model to examine the roles of misinformation beliefs, perceived risk, fear, worry, and social networks in explaining COVID-19 vaccination intentions. We tested the model using survey data of South Korean adults, collected when the Korean government launched its nationwide vaccination program in April 2021 (n = 744). The results from our step-by-step path analyses indicated that COVID-19 vaccination intentions had positive direct associations with vaccination-specific factors such as attitudes toward, injunctive norms on, and perceived behavioral control over COVID-19 vaccination. Perceived risk was also directly linked to intentions. Among these factors, attitudes and injunctive norms were most strongly related to intentions. Misinformation beliefs and worry had negative indirect relationships with intentions via the mediation of these variables directly connected to intentions. The negative influences of misinformation beliefs were greater among respondents reported stronger tie strengths. Theoretical and practical implications were discussed.

The Role of Deliberative Cognitive Styles in Preventing Belief in Politicized COVID-19 Misinformation.

Misinformation related to COVID-19 is a threat to public health. The present study examined the potential for deliberative cognitive styles such as actively open-minded thinking and need for evidence in deterring belief in misinformation and promoting belief in true information related to COVID-19. In addition, regarding how responses to the pandemic have been politicized, the role of political orientation and motivated reasoning were also examined. We conducted a survey in South Korea (N = 1466) during May 2020. Participants answered measures related to demographics, open-minded thinking, need for evidence, and accuracy perceptions of COVID-19 misinformation and true information items. Multi-level analyses of the survey data found that while motivated reasoning was present, deliberative cognitive styles (actively open-minded thinking and need for evidence) decreased belief in misinformation without intensifying motivated reasoning tendencies. Findings also showed a political asymmetry where conservatives detected COVID-19 misinformation at a lesser rate. Overall, results suggest that health communication related to COVID-19 misinformation should pay attention to conservative populations. Results also imply that interventions that activate deliberative cognitive styles hold promise in reducing belief in COVID-19 misinformation.

In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology.

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began in 2019 but it remains as a serious threat today. To reduce and prevent spread of the virus, multiple vaccines have been developed. Despite the efforts in developing vaccines, Omicron strain of the virus has recently been designated as a variant of concern (VOC) by the World Health Organization (WHO). OBJECTIVE: To develop a vaccine candidate against Omicron strain (B.1.1.529, BA.1) of the SARS-CoV-19. METHODS: We applied reverse vaccinology methods for BA.1 and BA.2 as the vaccine target and a control, respectively. First, we predicted MHC I, MHC II and B cell epitopes based on their viral genome sequences. Second, after estimation of antigenicity, allergenicity and toxicity, a vaccine construct was assembled and tested for physicochemical properties and solubility. Third, AlphaFold2, RaptorX and RoseTTAfold servers were used to predict secondary structures and 3D structures of the vaccine construct. Fourth, molecular docking analysis was performed to test binding of our construct with angiotensin converting enzyme 2 (ACE2). Lastly, we compared mutation profiles on the epitopes between BA.1, BA.2, and wild type to estimate the efficacy of the vaccine. RESULTS: We collected a total of 10 MHC I, 9 MHC II and 5 B cell epitopes for the final vaccine construct for Omicron strain. All epitopes were predicted to be antigenic, non-allergenic and non-toxic. The construct was estimated to have proper stability and solubility. The best modelled tertiary structures were selected for molecular docking analysis with ACE2 receptor. CONCLUSIONS: These results suggest the potential efficacy of our newly developed vaccine construct as a novel vaccine candidate against Omicron strain of the coronavirus.

Young people are not blameworthy: the generation's awareness of COVID-19 and behavioral responses.

At a time when the COVID-19 pandemic has been ongoing for more than a year, young people have been the subject of vigilant scrutiny and criticism regarding their active engagement in social activities. We posed the question of whether young people's response to COVID-19 was different from that of other generations and analyzed awareness and behavior to investigate this question. Specifically, we examined internet searches for information on COVID-19 and credit card consumption in South Korea among young people in their 20s and compared them to a reference group of people in their 50s. Our research has confirmed that there was no statistically significant difference between young people and the reference group in this regard. Furthermore, in the 25 sub-sectors of industry we examined, young people's consumption activities recovered significantly faster than the reference group in only three sub-sectors. This study demonstrated that young people showed stronger interest than the reference group in their response to COVID-19, and that they cooperated with the government's social distancing policy by reducing their activities. Through this study, we presented a scientific approach for evaluating young people in regard to their response to COVID-19, offering useful implications for designing appropriate policies for public health.

Specific Treatment Exists for SARS-CoV-2 ARDS.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seems to be difficult to overcome. A pandemic of such a scale has not been seen since the 1918 influenza pandemic. Although the predominant clinical presentation is respiratory disease, neurological manifestations and sequelae are increasingly being recognized. We observed a case series of rapid recovery of ARDS within 24 h in the preliminary clinical features of COVID-19 ARDS-associated neurological disease. It was also noted that by 15 April, 2021, there was no SARS-CoV-2 ARDS on Sorok Island in South Korea, where lepers had been living together. We compared each of dapsone's effects on humans and considered those of SARS-CoV-2. Dapsone showed different effects in the brain. The Sorokdo National Hospital reported a relationship between dapsone and the neuroinflammasome of Alzheimer's disease (AD) in Sorok Island from January 2005 to June 2020. AD prevalence was low in the leprosy patient group who took dapsone regularly. The preliminary cross-sectional study of the trial group (22 subjects) and the control group (22 subjects) in the Hunt Regional Hospital reported the following results: The chi-square statistic is 5.1836. The p-value is 0.022801. The result is considered significant at p < 0.05. The results from the medical treatment from 21 December to 29 December 2020 were considered. The mortality rates at the ARDS onset stage were 0% with dapsone administered as a standard COVID-19 treatment and 40% without dapsone administered as a standard COVID-19 treatment, respectively. Based on the respiratory failure and sudden high death rate originating from the involvement of the brainstem, especially the pre-Bötzinger complex, dapsone can be used to significantly reduce the incidence of the cases of acute respiratory distress syndrome and other illnesses caused by SARS-CoV-2.

Toward More Effective Public Health Interventions during the COVID-19 Pandemic: Suggesting Audience Segmentation Based on Social and Media Resources.

In response to the COVID-19 pandemic, public health communication campaigns have been targeted at reducing viral transmission, specifically among populations most vulnerable to infection and death from the virus (e.g. older adults). However, other individuals who have not been defined as vulnerable populations may also suffer from a decrease in health because of the measures aimed at reducing viral transmission, such as social distancing. To illuminate this issue, we investigate the role of social and media resources in complementing limited offline communication and supporting mental and physical health during this pandemic. We then suggest an alternative audience segmentation strategy based on social and media resources for public health interventions. Based on online survey data from 723 adults in South Korea, the regression analysis results indicated that individuals with lower levels of social resources suffered more during the pandemic. The cluster analysis results revealed that, contrary to the traditional definition of vulnerable populations, a cluster of younger people were unhealthier than a cluster of older people because of a lack of social resources. Clusters with different levels of ICT skills and uses for health-related activities also experienced the pandemic differently. These findings imply public health interventions should focus on social resources beyond the demographic factors to determine target audiences, and that they should take advantage of the target audiences' media resources to encourage them to forge intimate connections with others and to engage in health-related activities.